Stevens-Johnson Syndrome From Heterologous COVID-19 Vaccine: A Case Report

Abstract

Stevens-Johnson syndrome is an acute hypersensitivity reaction which leads to generalized necrosis of the skin and mucous membranes that is often drug-induced. Other possible causative factors are bacterial and viral infections. Vaccination-induced Stevens-Johnson syndrome is a rare occurrence. In this paper, we reported a case of Stevens-Johnson syndrome in a 62-year-old male, 1 week after receiving the third dose of coronavirus disease 2019 (COVID-19) vaccine. His initial two doses were an inactivated form of the whole-virus vaccine given 6 months ago. His third dose was an mRNA COVID-19 vaccine. This case demonstrates a rare dermatological complication using heterologous vaccines.

Clin Infect Immun. 2022;7(2):58-61
doi: https://doi.org/10.14740/cii153