Primary Cutaneous Histoplasmosis With Disseminated Tuberculosis as an Initial Presentation of AIDS

Abstract

A previously healthy young male patient who presented with significant weight loss and multiple cutaneous ulcerative papular lesions on the face was detected to be positive for human immunodeficiency virus (HIV) infection with very low CD4 counts (14/µL). Histoplasma capsulatumwas isolated from the scrapings of cutaneous lesions. He was also detected to have evidence of concomitant disseminated tuberculosis (TB) infection with pulmonary and bone marrow involvement. He was managed with liposomal amphotericin, itraconazole, anti-tubercular and anti-retroviral therapy. Subsequently, he developed marked pancytopenia which reverted successfully with blood component replacement therapy. He gradually attained a good immunological and clinical recovery.




Clin Infect Immun. 2017;2(2-3):43-45
doi: https://doi.org/10.14740/cii32w